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Title | ACETYLCHOLINE RECEPTOR BINDING ANTIBODIES |
Specimen Requirement | <p>1 SST/1.0 mL serum. After 30 minutes of clotting, promptly centrifuge.</p> |
Methodology | |
Stability | Room Temperature 14 days; Refrigerated 14 days; Frozen 30 days |
Reference Range | By Report* |
Turnaround | 5-8 days Performed Sun, Tues, Thurs |
Clinical Use | <p>Myasthenia gravis (MG), the most common neuromuscular transmission disorder, is an antibody-mediated autoimmune disease that stems from a loss of acetylcholine receptors (AChR) at neuromuscular junctions. AChR autoantibodies are diagnostic of MG, and are found in 85-90% of MG patients. AChR binding autoantibodies are present most frequently in MG and provide the most reliable information for diagnostic screening. A small portion of patients with early onset or ocular restricted MG may only have AChR modulating autoantibodies, thus if AChR binding autoantibodies are absent in a patient with weakness or ocular symptoms consistent with MG, AChR modulating autoantibodies should be ordered. AChR blocking autoantibodies are directed against the neurotransmitter-binding site and may be the only AChR autoantibody in about 1% of MG patients.</p> |
Test Code | ACRB |
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