TP53 SOMATIC MUTATION, PROGNOSTIC

<p>6 mL whole blood collected in an EDTA (lavender top) tube</p>

 

Room Temperature: 72 hours; Refrigerated: 7 days; Frozen: Unaccepatable

 

5-7 Days Performed Tues, Thurs

<p>Somatic mutation of the p53 tumor suppressor gene is the most common genetic alteration seen in human cancers, with &gt;50% of adult human tumors bearing inactivating mutations or insertions, deletions in the P53 gene.&nbsp; Wild type p53 prevents genetic instability and participates in the apoptotic response to radiotherapy and chemotherapy.&nbsp; Mutations in P53 gene usually correlate with poor outcome and early recurrence in cancer.&nbsp; This test provides important prognostic and prodictive information for patients with B-CLL, breast cancer, cervical cancer, melanoma or other cancers.</p>

TP53S